Tangential Migration in Neocortical Development
نویسندگان
چکیده
منابع مشابه
Tangential migration of neocortical neurons in early human foetuses.
The aim of the present study is to describe the tangential migration of cortical neurons in early human foetuses aged 9-11 weeks. Histological sections showed that in this early period of development most of the neurons migrate along radial glia, but there is also tangential migration, especially from the lateral eminence.
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Necdin is a pleiotropic protein that promotes neuronal differentiation and survival. In mammals, the necdin gene on the maternal chromosome is silenced by genomic imprinting, and only the paternal necdin gene is expressed in virtually all postmitotic neurons. Necdin forms a complex with the homeodomain protein Dlx2 to enhance its transcriptional activity. Dlx2 plays a major role in controlling ...
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The early-generated neurons designated as lot cells specifically mark the future site of the lateral olfactory tract (LOT) and guide LOT axons. We investigated the mechanism of how lot cells develop and get localized in the LOT position. Lot cells differentiated from neuroepithelial cells in all regions of the neocortex but not from those in the ganglionic eminence in culture. Cell tracing anal...
متن کاملMultimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins.
Neuronal migration is crucial for the construction of neuronal architecture such as layers and nuclei. Most inhibitory interneurons in the neocortex derive from the basal forebrain and migrate tangentially; however, little is known about the mode of migration of these neurons in the cortex. We used glutamate decarboxylase (Gad)67-green fluorescent protein (GFP) knock-in embryonic mice with expr...
متن کاملConserved pattern of tangential neuronal migration during forebrain development.
Origin, timing and direction of neuronal migration during brain development determine the distinct organization of adult structures. Changes in these processes might have driven the evolution of the forebrain in vertebrates. GABAergic neurons originate from the ganglionic eminence in mammals and migrate tangentially to the cortex. We are interested in differences and similarities in tangential ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2002
ISSN: 0012-1606
DOI: 10.1006/dbio.2002.0586